Why the test is performed
To identify selected EGFR alterations that may help classify a tumour and guide targeted-treatment decisions.
World time
Laboratory Testing Online / Molecular Pathology
EGFR Tumour Mutation Test
To identify selected EGFR alterations that may help classify a tumour and guide targeted-treatment decisions.Test profileMOEGFR Tumour Mutation Test
Test and specimen
What is being examined?
- Test
- EGFR Tumour Mutation Test
- Department
- Molecular Pathology
- Typical sample or measurement
- Tumour tissue or validated circulating tumour DNA
Before the test
Testing is ordered by the oncology/pathology team. Adequate tumour content and awareness of assay limits are crucial.
Clinical interpretation
Laboratory results should be interpreted by a qualified professional using the correct reference interval, method, symptoms, history and other findings. A normal or abnormal value rarely confirms or excludes a condition by itself.
What the test is used for
Most commonly in selected non-small-cell lung cancer pathways, under oncology guidance.
How the test is performed
DNA from tumour or plasma is analysed by a validated PCR, sequencing or next-generation sequencing method with defined detection limits.
Conditions and diseases considered
Used in molecular profiling of non-small-cell lung cancer and selected other tumours; a negative plasma test may require tissue testing.
Recommended further tests
Broader tumour panel, ALK/ROS1 or other biomarkers, PD-L1 testing and pathology/imaging correlation.
Primary public reference
Continue with the official patient guide.
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